An efflux pump deletion mutant enabling the discovery of a macrolide as an overlooked anti-P. aeruginosa active compound
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology
Link
https://www.nature.com/articles/s41429-023-00607-0.pdf
Reference17 articles.
1. Murray CJL, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399:629–55.
2. Willyard C. The drug-resistant bacteria that pose the greatest health threats. Nature. 2017;543:15.
3. Bodey GP, Bolivar R, Fainstein V, Jadeja L. Infections caused by Psudomonas aeruginosa. Rev Infect Dis. 1983;5:279–313.
4. Malhotra S, Hayes D Jr, Wozniak DJ. Cystic fibrosis and Pseudomonas aeruginosa: the host-microbe interface. Clin Microbiol Rev. 2019;32:e00138–18.
5. Stoitsova SO, Bruan Y, Ullrich MS, Weingart H. Charactarization of the RND-type multidrug efflux pump MexAB-OprM of the plant pathogen Pseudomonas syringae. Appl Environ Microbiol. 2008;74:3387–93.
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1. Efflux pump inhibitor, phenylalanine-arginine beta-naphthylamide analog potentiates the activity of 5-O-mycaminosyltylonolide for multi-drug resistant Pseudomonas aeruginosa;The Journal of Antibiotics;2024-03-11
2. A combination strategy of a semisynthetic macrolide, 5-O-mycaminosyltylonolide with polymyxin B nonapeptide for multi-drug resistance P. aeruginosa;The Journal of Antibiotics;2023-05-19
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