Biosynthesis of the nucleoside antibiotic angustmycins: identification and characterization of the biosynthetic gene cluster reveal unprecedented dehydratase required for exo-glycal formation-Reference-Cited by-同舟云学术

Biosynthesis of the nucleoside antibiotic angustmycins: identification and characterization of the biosynthetic gene cluster reveal unprecedented dehydratase required for exo-glycal formation

Published:2021-08-17 Issue:11 Volume:74 Page:830-833
ISSN:0021-8820
Container-title:The Journal of Antibiotics
language:en
Short-container-title:J Antibiot

Author:

Shiraishi Taro^ORCID,Xia Jiaqi,Kato Teruhito,Kuzuyama Tomohisa^ORCID

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology

Link

https://www.nature.com/articles/s41429-021-00466-7.pdf

Reference20 articles.

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2. Frédéric CJM, Vincent SP. Synthesis of exo-glycals and their biochemical applications. Tetrahedron. 2018;74:6512–9.

3. Wyszynski FJ, Lee SS, Yabe T, Wang H, Gomez-Escribano JP, Bibb MJ, et al. Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates. Nat Chem. 2012;4:539–46.

4. Li Z, Hwang S, Ericson J, Bowler K, Bar-Peled M. Pen and pal are nucleotide-sugar dehydratases that convert UDP-GlcNAc to UDP-6-deoxy-d-GlcNAc-5,6-ene and then to UDP-4-keto-6-deoxy-l-AltNAc for CMP-pseudaminic acid synthesis in Bacillus thuringiensis. J Biol Chem. 2015;290:691–704.

5. Lamberth C. The chemistry of 4′, 5′-unsaturated nucleosides. A review. Org Prep Proced Int. 1999;31:379–97.

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