Exploring genetic interactions and networks with yeast
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics(clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg2085.pdf
Reference88 articles.
1. Davierwala, A. P. et al. The synthetic genetic interaction spectrum of essential genes. Nature Genet. 37, 1147–1152 (2005). This paper describes the first major application of SGA analysis to mapping of genetic-interaction networks among essential genes, and reveals that they seem to act as highly connected hubs on the network.
2. Tong, A. H. Y. et al. Global mapping of the yeast genetic interaction network. Science 303, 808–813 (2004). This study describes large-scale mapping of synthetic-lethal genetic interactions in yeast by SGA analysis. The results highlight the utility of genetic networks for discovering gene function and define the topology and general properties of genetic networks.
3. Hughes, T. R., Robinson, M. D., Mitsakakis, N. & Johnston, M. The promise of functional genomics: completing the encyclopedia of a cell. Curr. Opin. Microbiol. 7, 546–554 (2004).
4. Dolinski, K. & Botstein, D. Changing perspective in yeast research nearly a decade after the genome sequence. Genome Res. 15, 1611–1619 (2006).
5. Giaever, G. et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature 418, 387–391 (2002). A landmark paper that describes the construction and use of the yeast deletion-mutant collection.
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