Safe harbours for the integration of new DNA in the human genome

Author:

Sadelain Michel,Papapetrou Eirini P.,Bushman Frederic D.

Publisher

Springer Science and Business Media LLC

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference86 articles.

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2. Aiuti, A. et al. Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy. J. Clin. Invest. 117, 2233–2240 (2007).

3. Gaspar, H. B. et al. Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction. Sci. Transl. Med. 3, 97ra80 (2011).

4. Riviere, I., Dunbar, C. & Sadelain, M. Hematopoietic stem cell engineering at a crossroads. Blood 17 Nov 2011 (doi:10.1182/blood-2011-09-349993).

5. Martin, D. I. & Whitelaw, E. The vagaries of variegating transgenes. Bioessays 18, 919–923 (1996).

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