Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis-Reference-Cited by-同舟云学术

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Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis

Published:2012-10-22 Issue:2 Volume:93 Page:151-158
ISSN:0023-6837
Container-title:Laboratory Investigation
language:en
Short-container-title:Lab Invest

Author:

Koczor Christopher A,Torres Rebecca A,Fields Earl,Qin Qianhong,Park Jade,Ludaway Tomika,Russ Rodney,Lewis William

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology,Pathology and Forensic Medicine

Link

http://www.nature.com/articles/labinvest2012146.pdf

Reference28 articles.

1. Neubauer S . The failing heart--an engine out of fuel. N Engl J Med 2007;356:1140–1151.

2. Kohler JJ, Hosseini SH, Green E et al. Cardiac-targeted transgenic mutant mitochondrial enzymes: mtDNA defects, antiretroviral toxicity and cardiomyopathy. Cardiovasc Toxicol 2008;8:57–69.

3. Lewis W, Day BJ, Kohler JJ et al. Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma. Lab Invest 2007;87:326–335.

4. Kohler JJ, Hosseini SH, Lewis W et al. Mitochondrial DNA impairment in nucleoside reverse transcriptase inhibitor-associated cardiomyopathy. Chem Res Toxicol 2008;21:990–996.

5. Karamanlidis G, Nascimben L, Couper GS et al. Defective DNA replication impairs mitochondrial biogenesis in human failing hearts. Circ Res 2010;106:1541–1548.

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