HP1 reshapes nucleosome core to promote phase separation of heterochromatin-Reference-Cited by-同舟云学术

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HP1 reshapes nucleosome core to promote phase separation of heterochromatin

Published:2019-10-16 Issue:7782 Volume:575 Page:390-394
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Sanulli S.,Trnka M. J.,Dharmarajan V.,Tibble R. W.,Pascal B. D.,Burlingame A. L.,Griffin P. R.,Gross J. D.,Narlikar G. J.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41586-019-1669-2.pdf

Reference49 articles.

1. Stephens, A. D. et al. Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins. Mol. Biol. Cell 29, 220–233 (2018).

2. Allshire, R. C. & Madhani, H. D. Ten principles of heterochromatin formation and function. Nat. Rev. Mol. Cell Biol. 19, 229–244 (2018).

3. Canzio, D. et al. Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Mol. Cell 41, 67–81 (2011).

4. Canzio, D. et al. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature 496, 377–381 (2013).

5. Larson, A. G. et al. Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin. Nature 547, 236–240 (2017).

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