Structures of the σ2 receptor enable docking for bioactive ligand discovery-Reference-Cited by-同舟云学术

Structures of the σ2 receptor enable docking for bioactive ligand discovery

Published:2021-12-08 Issue:7890 Volume:600 Page:759-764
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Alon Assaf^ORCID,Lyu Jiankun^ORCID,Braz Joao M.^ORCID,Tummino Tia A.^ORCID,Craik Veronica^ORCID,O’Meara Matthew J.^ORCID,Webb Chase M.,Radchenko Dmytro S.^ORCID,Moroz Yurii S.^ORCID,Huang Xi-Ping,Liu Yongfeng^ORCID,Roth Bryan L.^ORCID,Irwin John J.,Basbaum Allan I.^ORCID,Shoichet Brian K.^ORCID,Kruse Andrew C.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

https://www.nature.com/articles/s41586-021-04175-x.pdf

Reference77 articles.

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3. Sahn, J. J., Mejia, G. L., Ray, P. R., Martin, S. F. & Price, T. J. Sigma 2 receptor/Tmem97 agonists produce long lasting antineuropathic pain effects in mice. ACS Chem. Neurosci. 8, 1801–1811 (2017).

4. Intagliata, S. et al. Discovery of a highly selective sigma-2 receptor ligand, 1-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with drug-like properties and antinociceptive effects in vivo. AAPS J. 22, 94 (2020).

5. Quadir, S. G. et al. The Sigma-2 receptor / transmembrane protein 97 (σ2R/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice. Neuropharmacology 184, 108409 (2021).

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