A Cdk9–PP1 switch regulates the elongation–termination transition of RNA polymerase II
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41586-018-0214-z.pdf
Reference43 articles.
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2. Davidson, L., Muniz, L. & West, S. 3′ end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells. Genes Dev. 28, 342–356 (2014).
3. Sansó, M. et al. P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates. Genes Dev. 30, 117–131 (2016).
4. Grallert, A. et al. A PP1–PP2A phosphatase relay controls mitotic progression. Nature 517, 94–98 (2015).
5. Shetty, A. et al. Spt5 plays vital roles in the control of sense and antisense transcription elongation. Mol. Cell 66, 77–88.e75 (2017).
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