Affiliation:
1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Abstract
An end to gene transcription
Much attention has been focused on regulating the start of gene transcription. But transcription must also be terminated, and the mechanisms are only now being defined in detail in eukaryotes. Proudfoot reviews how termination happens for RNA polymerase II genes, mainly in mammals, covering the various steps that can lead to messenger RNA (mRNA) 3′ end formation and how they can be regulated. Termination can occur at various positions throughout the gene, forming the wild-type mRNA, preventing the synthesis of aberrant mRNAs, or generating alternative mRNAs with different regulatory or coding properties.
Science
, this issue p.
10.1126/science.aad9926
Funder
Wellcome Trust
European Research Council
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
333 articles.
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