PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism-Reference-Cited by-同舟云学术

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

Published:2021-04-28 Issue:7862 Volume:594 Page:271-276
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Ren Aileen A.^ORCID,Snellings Daniel A.^ORCID,Su Yourong S.,Hong Courtney C.^ORCID,Castro Marco^ORCID,Tang Alan T.^ORCID,Detter Matthew R.^ORCID,Hobson Nicholas,Girard Romuald^ORCID,Romanos Sharbel,Lightle Rhonda,Moore Thomas,Shenkar Robert^ORCID,Benavides Christian,Beaman M. Makenzie^ORCID,Müller-Fielitz Helge^ORCID,Chen Mei,Mericko Patricia,Yang Jisheng,Sung Derek C.^ORCID,Lawton Michael T.,Ruppert J. Michael,Schwaninger Markus^ORCID,Körbelin Jakob^ORCID,Potente Michael^ORCID,Awad Issam A.,Marchuk Douglas A.^ORCID,Kahn Mark L.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41586-021-03562-8.pdf

Reference50 articles.

1. Cuttano, R. et al. KLF4 is a key determinant in the development and progression of cerebral cavernous malformations. EMBO Mol. Med. 8, 6–24 (2015).

2. Zhou, Z. et al. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature 532, 122–126 (2016).

3. Renz, M. et al. Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins. Dev. Cell 32, 181–190 (2015).

4. Otten, C. et al. Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations. EMBO Mol. Med. 10, e9155 (2018).

5. Tang, A. T. et al. Endothelial TLR4 and the microbiome drive cerebral cavernous malformations. Nature 545, 305–310 (2017).

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