Mechanism for Cas4-assisted directional spacer acquisition in CRISPR

Mechanism for Cas4-assisted directional spacer acquisition in CRISPR–Cas

Published:2021-09-29 Issue:7881 Volume:598 Page:515-520
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Hu Chunyi,Almendros Cristóbal,Nam Ki Hyun^ORCID,Costa Ana Rita^ORCID,Vink Jochem N. A.,Haagsma Anna C.,Bagde Saket R.,Brouns Stan J. J.^ORCID,Ke Ailong^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

https://www.nature.com/articles/s41586-021-03951-z.pdf

Reference55 articles.

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3. Nuñez, J. K. et al. Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity. Nat. Struct. Mol. Biol. 21, 528–534 (2014).

4. Nuñez, J. K., Lee, A. S., Engelman, A. & Doudna, J. A. Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity. Nature 519, 193–198 (2015).

5. Mojica, F. J., Diez-Villasenor, C., Garcia-Martinez, J. & Almendros, C. Short motif sequences determine the targets of the prokaryotic CRISPR defence system. Microbiology 155, 733–740 (2009).

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