Abstract
AbstractThe Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.
Publisher
Springer Science and Business Media LLC
Reference71 articles.
1. Claussnitzer, M. et al. A brief history of human disease genetics. Nature 577, 179–189 (2020).
2. Hiller, M. et al. A “forward genomics” approach links genotype to phenotype using independent phenotypic losses among related species. Cell Rep. 2, 817–823 (2012).
3. Wasser, S. K. et al. Genetic assignment of large seizures of elephant ivory reveals Africa’s major poaching hotspots. Science 349, 84–87 (2015).
4. Wright, B. et al. Development of a SNP-based assay for measuring genetic diversity in the Tasmanian devil insurance population. BMC Genomics 16, 791 (2015).
5. Lappalainen, T., Scott, A. J., Brandt, M. & Hall, I. M. Genomic analysis in the age of human genome sequencing. Cell 177, 70–84 (2019).