Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR-Reference-Cited by-同舟云学术

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR

Published:2014-11-25 Issue:1 Volume:5 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Henze Anne-Theres,Garvalov Boyan K.,Seidel Sascha,Cuesta Angel M.,Ritter Mathias,Filatova Alina,Foss Franziska,Dopeso Higinio,Essmann Clara L.,Maxwell Patrick H.,Reifenberger Guido,Carmeliet Peter,Acker-Palmer Amparo,Acker Till

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms6582.pdf

Reference54 articles.

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3. Bruick, R. K. & McKnight, S. L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337–1340 (2001).

4. Epstein, A. C. et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107, 43–54 (2001).

5. Kaelin, W. G. Jr. & Ratcliffe, P. J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 30, 393–402 (2008).

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