Influence of CYP2B6 activity score on the pharmacokinetics and safety of single dose efavirenz in healthy volunteers-Reference-Cited by-同舟云学术

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Influence of CYP2B6 activity score on the pharmacokinetics and safety of single dose efavirenz in healthy volunteers

Published:2019-10-18 Issue:2 Volume:20 Page:235-245
ISSN:1470-269X
Container-title:The Pharmacogenomics Journal
language:en
Short-container-title:Pharmacogenomics J

Author:

Zubiaur Pablo,Saiz-Rodríguez Miriam^ORCID,Ochoa Dolores,Belmonte Carmen,Román Manuel,Mejía Gina,Martín-Vilchez Samuel,Abad-Santos Francisco^ORCID

Funder

P. Zubiaur is co-financed by Consejería de Educación, Juventud y Deporte from Comunidad de Madrid and European Social Fund.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,Genetics,Molecular Medicine

Link

http://www.nature.com/articles/s41397-019-0103-3.pdf

Reference42 articles.

1. Duarte H, Cruz JP, Aniceto N, Ribeiro AC, Fernandes A, Paixão P, et al. Population approach to efavirenz therapy. J Pharm Sci. 2017;106:3161–6.

2. Siberry GK, Abzug MJ, Nachman S, Brady MT, Dominguez KL, Handelsman E, et al. Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected Children: Recommendations from the National Institutes of Health, Centers for Disease Control and Prevention, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics. Pediatr Infect Dis J. 2013;32:i.

3. FDA. Efavirenz 600mg. FDA. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/091471Orig1s000lbl.pdf .

4. Ogburn ET, Jones DR, Masters AR, Xu C, Guo Y, Desta Z. Efavirenz primary and secondary metabolism in vitro and in vivo: identification of novel metabolic pathways and cytochrome P450 2A6 as the principal catalyst of efavirenz 7-hydroxylation. Drug Metab Dispos. 2010;38:1218–29.

5. Ngaimisi E, Mugusi S, Minzi OM, Sasi P, Riedel K-D, Suda A, et al. Long-term efavirenz autoinduction and its effect on plasma exposure in HIV patients. Clin Pharm Ther. 2010;88:676–84.

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