5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity

Author:

Sugawara AkihiroORCID,Maruyama Hitomi,Shibusawa Sho,Matsui Hidehito,Hirose Tomoyasu,Tsutsui Ayumi,Froyman Robrecht,Ludwig Carolin,Koebberling Johannes,Hanaki Hideaki,Kleefeld Gerd,Ōmura Satoshi,Sunazuka Toshiaki

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology

Reference22 articles.

1. Ōmura, S. in: Macrolide Antibiotics. Chemistry, Biology, and Practice 2nd edn (ed. Ōmura, S.) (Academic Press, San Diego, 2002).

2. Hamill, R. L., Haney, M. E. Jr, Stamper, M. & Wiley, P. F. Tylosin, a new antibiotic. II. Isolation, properties, and preparation of desmycosin, a microbiologically active degradation product. Antibiot. Chemother. 328–334 (1961).

3. Ōmura, S. Microbial metabolites: 45 years of wandering, wondering and discovering. Tetrahedron 67, 6420–6459 (2011).

4. Debono, M. et al. Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-dimethylpiperidin-l-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives. J. Antibiot. 42, 1253–1267 (1989).

5. Miyake, T., Takita, M., Hamada, M., Takeuchi, T. & Umezawa, S. (Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai). Macrolide antibiotics and treatment of pasteurellosis. WO2001016148A1 (2001).

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