Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetes
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology
Link
https://www.nature.com/articles/ja201751.pdf
Reference23 articles.
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3. Scherlach, K. & Hertweck, C. Triggering cryptic natural product biosynthesis in microorganisms. Org. Biomol. Chem. 7, 1753–1760 (2009).
4. Zarins-Tutt, J. S. et al. Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products. Nat. Prod. Rep. 33, 54–72 (2016).
5. Ochi, K. Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects. J. Antibiot. (Tokyo) 70, 25–40 (2017).
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