Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo

Author:

Begleiter A,Leith M K,Thliveris J A,Digby T

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference50 articles.

1. Beall HD, Murphy AM, Siegel D, Hargreaves RHJ, Butler J, Ross D (1995) Nicotinamide adenine dinucleotide (phosphate):quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines. Mol Pharmacol 48: 499–504

2. Begleiter A (2000) Clinical applications of quinone alkylating agents. Front Biosci 5: e153–e171

3. Begleiter A, Leith MK (1993) Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under acidic conditions. Mol Pharmacol 44: 210–215

4. Begleiter A, Leith MK, Curphey TJ (1996) Induction of DT-diaphorase by 1,2-dithiole-3-thione and increase of antitumour activity of bioreductive agents. Br J Cancer 74(Suppl 27): S9–S14

5. Begleiter A, Robotham E, Lacey G, Leith MK (1989) Increased sensitivity of quinone resistant cells to mitomycin C. Cancer Lett 45: 173–176

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