Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome-Reference-Cited by-同舟云学术

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

Published:2022-09-29 Issue:10 Volume:29 Page:966-977
ISSN:1545-9993
Container-title:Nature Structural & Molecular Biology
language:en
Short-container-title:Nat Struct Mol Biol

Author:

Bonsor Daniel A.,Alexander Patrick,Snead Kelly,Hartig Nicole,Drew Matthew,Messing Simon,Finci Lorenzo I.,Nissley Dwight V.^ORCID,McCormick Frank^ORCID,Esposito Dominic^ORCID,Rodriguez-Viciana Pablo,Stephen Andrew G.^ORCID,Simanshu Dhirendra K.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Structural Biology

Link

https://www.nature.com/articles/s41594-022-00841-4.pdf

Reference82 articles.

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2. Yaeger, R. & Corcoran, R. B. Targeting alterations in the RAF–MEK pathway. Cancer Discov. 9, 329–341 (2019).

3. Longo, J. F. & Carroll, S. L. The RASopathies: biology, genetics and therapeutic options. Adv. Cancer Res 153, 305–341 (2022).

4. Lavoie, H. & Therrien, M. Regulation of RAF protein kinases in ERK signalling. Nat. Rev. Mol. Cell Biol. 16, 281–298 (2015).

5. Park, E. et al. Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes. Nature 575, 545–550 (2019).

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