Family-based designs in the age of large-scale gene-association studies
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg1839.pdf
Reference75 articles.
1. Risch, N. & Merikangas, K. The future of genetics studies of complex human diseases. Science 273, 1516–1517 (1996). Shows that genome-wide association scans based on trios have greater power than genome-wide linkage scans based on affected sib pairs.
2. Clayton, D. G. et al. Population structure, differential bias and genomic control in a large-scale, case–control association study. Nature Genet. 37, 1243–1246 (2005).
3. Freedman, M. L. et al. Assessing the impact of population stratification on genetic association studies. Nature Genet. 36, 388–393 (2004).
4. McGinnis, R. General equations for Pt, Ps, and the power of the TDT and the affected-sib-pair test. Am. J. Hum. Genet. 67, 1340–1347 (2000).
5. McGinnis, R., Shifman, S. & Darvasi, A. Power and efficiency of the TDT and case–control design for association scans. Behav. Genet. 32, 135–144 (2002).
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