Assessing the impact of population stratification on genetic association studies

Author:

Freedman Matthew L,Reich David,Penney Kathryn L,McDonald Gavin J,Mignault Andre A,Patterson Nick,Gabriel Stacey B,Topol Eric J,Smoller Jordan W,Pato Carlos N,Pato Michele T,Petryshen Tracey L,Kolonel Laurence N,Lander Eric S,Sklar Pamela,Henderson Brian,Hirschhorn Joel N,Altshuler David

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Reference29 articles.

1. Thomas, D.C. & Witte, J.S. Point: population stratification: a problem for case-control studies of candidate-gene associations? Cancer Epidemiol. Biomarkers Prev. 11, 505–512 (2002).

2. Wacholder, S., Rothman, N. & Caporaso, N. Counterpoint: bias from population stratification is not a major threat to the validity of conclusions from epidemiological studies of common polymorphisms and cancer. Cancer Epidemiol. Biomarkers Prev. 11, 513–520 (2002).

3. Ziv, E. & Burchard, E.G. Human population structure and genetic association studies. Pharmacogenomics 4, 431–441 (2003).

4. Cardon, L.R. & Palmer, L.J. Population stratification and spurious allelic association. Lancet 361, 598–604 (2003).

5. Ardlie, K.G., Lunetta, K.L. & Seielstad, M. Testing for population subdivision and association in four case-control studies. Am. J. Hum. Genet. 71, 304–311 (2002).

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