Role and mechanism of action of leucine-rich repeat kinase 1 in bone

Author:

Xing Weirong R,Goodluck Helen,Zeng Canjun,Mohan Subburaman

Abstract

Abstract Leucine-rich repeat kinase 1 (LRRK1) plays a critical role in regulating cytoskeletal organization, osteoclast activity, and bone resorption with little effect on bone formation parameters. Deficiency of Lrrk1 in mice causes a severe osteopetrosis in the metaphysis of the long bones and vertebrae bones, which makes LRRK1 an attractive alternative drug target for the treatment of osteoporosis and other high-turnover bone diseases. This review summarizes recent advances on the functions of the Lrrk1-related family members, Lrrk1 deficiency-induced skeletal phenotypes, LRRK1 structure–function, potential biological substrates and interacting proteins, and the mechanisms of LRRK1 action in osteoclasts.

Publisher

Springer Science and Business Media LLC

Subject

Physiology,Histology,Endocrinology, Diabetes and Metabolism

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