Selective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep12222.pdf
Reference37 articles.
1. Pan, Y., Tsai, C. J., Ma, B. & Nussinov, R. How do transcription factors select specific binding sites in the genome? Nat Struct Mol Biol 16, 1118–1120 (2009).
2. Khorasanizadeh, S. & Rastinejad, F. Nuclear-receptor interactions on DNA-response elements. Trends Biochem Sci 26, 384–390 (2001).
3. Dilworth, F. J. & Chambon, P. Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription. Oncogene 20, 3047–3054 (2001).
4. Burris, T. P. et al. Nuclear receptors and their selective pharmacologic modulators. Pharmacol Rev 65, 710–778 (2013).
5. Woldt, E. et al. The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells. Nat Commun 3, 10 (2012).
Cited by 53 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Structure-based screening, optimization and biological evaluation of novel chrysin-based derivatives as selective PPARγ modulators for the treatment of T2DM and hepatic steatosis;European Journal of Medicinal Chemistry;2024-10
2. Phytochemistry and pharmacology of alkaloids from Papaver spp.: a structure–activity based study;Phytochemistry Reviews;2024-05-02
3. Raloxifene-driven benzothiophene derivatives: Discovery, structural refinement, and biological evaluation as potent PPARγ modulators based on drug repurposing;European Journal of Medicinal Chemistry;2024-04
4. Rational design of thiazolidine-4-one-gallic acid hybrid derivatives as selective partial PPARγ modulators: an in-silico approach for type 2 diabetes treatment;Journal of Biomolecular Structure and Dynamics;2023-11-24
5. Developmental toxicity induced by chelerythrine in zebrafish embryos via activating oxidative stress and apoptosis pathways;Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology;2023-11
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3