Cryptic genetic variation: evolution's hidden substrate
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics(clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg3688.pdf
Reference115 articles.
1. Gibson, G. Decanalization and the origin of complex disease. Nature Rev. Genet. 10, 134–140 (2009). This opinion article introduces the hypothesis that the genetic basis for diseases such as diabetes and asthma may include cryptic alleles that increase disease susceptibility in modern environments.
2. Gibson, G. & Dworkin, I. Uncovering cryptic genetic variation. Nature Rev. Genet. 5, 681–690 (2004).
3. Hermisson, J. & Wagner, G. P. The population genetic theory of hidden variation and genetic robustness. Genetics 168, 2271–2284 (2004). This paper builds the theory that genetic or environmental perturbations will release hidden variation under general conditions of G×G or G×E interactions, which indicates that CGV is not necessarily evidence of canalization or robustness.
4. Phillips, P. C. Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems. Nature Rev. Genet. 9, 855–867 (2008).
5. Masel, J. & Trotter, M. V. Robustness and evolvability. Trends Genet. 26, 406–414 (2010).
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