Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases
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Published:2023-11-20
Issue:1
Volume:10
Page:
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ISSN:2052-4463
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Container-title:Scientific Data
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language:en
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Short-container-title:Sci Data
Author:
Garrison McKinzie A.ORCID, Jang YeongjunORCID, Bae TaejeongORCID, Cherskov Adriana, Emery Sarah B., Fasching Liana, Jones AttilaORCID, Moldovan John B., Molitor Cindy, Pochareddy Sirisha, Peters Mette A., Shin Joo HeonORCID, Wang Yifan, Yang XiaoxuORCID, Akbarian SchahramORCID, Chess Andrew, Gage Fred H.ORCID, Gleeson Joseph G., Kidd Jeffrey M.ORCID, McConnell MichaelORCID, Mills Ryan E., Moran John V.ORCID, Park Peter J.ORCID, Sestan NenadORCID, Urban Alexander E.ORCID, Vaccarino Flora M.ORCID, Walsh Christopher A.ORCID, Weinberger Daniel R.ORCID, Wheelan Sarah J., Abyzov AlexejORCID, Amero Aitor Serres, Antaki Danny, Averbuj Dan, Ball Laurel, Bizzotto Sara, Bohrson Craig, Borges-Monroy Rebeca, Breuss Martin, Cho Sean, Chu Chong, Chung Changuk, Cortes-Ciriano Isidro, Coulter Michael, Daily Kenneth, Dias Caroline, D’Gama Alissa, Dou Yanmei, Erwin Jennifer, Flasch Diane A., Frisbie Trenton J., Galor Alon, Ganz Javier, Gulhan Doga, Hill Robert, Huang August Yue, Jaffe Andrew, Jourdon Alexandre, Juan David, Khoshkhoo Sattar, Kim Sonia, Kopera Huira C., Kwan Kenneth Y., Kwon Minseok, Langmead Ben, Lee Eunjung Alice, Linker Sara, Lobon Irene, Lodato Michael A., Luquette Lovelace J., Mathern Gary, Marques-Bonet Tomas, Maury Eduardo A., Miller Michael, Moruno Manuel Solis, Narurkar Rujuta, Paquola Apua, Pattni Reenal, Perez Raquel Garcia, Povolotskaya Inna, Reed Patrick, Rodin Rachel, Rosenbluh Chaggai, Scuderi Soraya, Sherman Maxwell, Straub Richard, Soriano Eduardo, Sun Chen, Thorpe Jeremy, Viswanadham Vinay, Wang Meiyan, Zhao Xuefang, Zhou Bo, Zhou Weichen, Zhou Zinan, Zhu Xiaowei,
Abstract
AbstractSomatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that plays a crucial role in normal development and disease. To study the nature and extent of somatic mosaicism in autism spectrum disorder, bipolar disorder, focal cortical dysplasia, schizophrenia, and Tourette syndrome, a multi-institutional consortium called the Brain Somatic Mosaicism Network (BSMN) was formed through the National Institute of Mental Health (NIMH). In addition to genomic data of affected and neurotypical brains, the BSMN also developed and validated a best practices somatic single nucleotide variant calling workflow through the analysis of reference brain tissue. These resources, which include >400 terabytes of data from 1087 subjects, are now available to the research community via the NIMH Data Archive (NDA) and are described here.
Funder
U.S. Department of Health & Human Services | National Institutes of Health National Science Foundation U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development U.S. Department of Health & Human Services | NIH | National Institute of Mental Health
Publisher
Springer Science and Business Media LLC
Subject
Library and Information Sciences,Statistics, Probability and Uncertainty,Computer Science Applications,Education,Information Systems,Statistics and Probability
Reference50 articles.
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