Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

Author:

McConnell Michael J.1ORCID,Moran John V.23ORCID,Abyzov Alexej4,Akbarian Schahram5ORCID,Bae Taejeong4ORCID,Cortes-Ciriano Isidro6ORCID,Erwin Jennifer A.7ORCID,Fasching Liana8,Flasch Diane A.2ORCID,Freed Donald910,Ganz Javier1112ORCID,Jaffe Andrew E.13ORCID,Kwan Kenneth Y.214ORCID,Kwon Minseok6,Lodato Michael A.1112ORCID,Mills Ryan E.215ORCID,Paquola Apua C. M.7ORCID,Rodin Rachel E.1112ORCID,Rosenbluh Chaggai16ORCID,Sestan Nenad17ORCID,Sherman Maxwell A.6,Shin Joo Heon13ORCID,Song Saera1819ORCID,Straub Richard E.13ORCID,Thorpe Jeremy910,Weinberger Daniel R.132021,Urban Alexander E.22ORCID,Zhou Bo22ORCID,Gage Fred H.7ORCID,Lehner Thomas23ORCID,Senthil Geetha23ORCID,Walsh Christopher A.1112,Chess Andrew16ORCID,Courchesne Eric24ORCID,Gleeson Joseph G.1819,Kidd Jeffrey M.215ORCID,Park Peter J.6,Pevsner Jonathan910ORCID,Vaccarino Flora M.825ORCID,Barton Alison R.,Bekiranov Stefan,Bohrson Craig L.,Burbulis Ian E.,Chronister William,Coppola Gianfilippo,Daily Kenneth,D’Gama Alissa M.,Emery Sarah B.,Frisbie Trenton J.,Gao Tianliuyun,Gulyás-Kovács Attila,Haakenson Mark,Keil Jason M.,Kopera Huira C.,Lam Mandy M.,Lee Eunjung Alice,Marques-Bonet Tomas,Mathern Gary W.,Moldovan John B.,Oetjens Matthew T.,Omberg Larsson,Peters Mette A.,Pochareddy Sirisha,Pramparo Tiziano,Ratan Aakrosh,Sanavia Tiziana,Shi Lei,Skarica Mario,Wang Jia,Wang Meiyan,Wang Yifan,Wierman Margaret,Wolpert Matthew,Woodworth Mollie,Zhao Xuefang,Zhou Weichen,

Affiliation:

1. Department of Biochemistry and Molecular Genetics, Department of Neuroscience, Center for Brain Immunology and Glia, Children’s Health Research Center, and Center for Public Health Genomics, University of Virginia School of Medicine, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA.

2. Department of Human Genetics, University of Michigan Medical School, 1241 East Catherine Street, Ann Arbor, MI 48109, USA.

3. Department of Internal Medicine, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.

4. Department of Health Sciences Research, Center for Individualized Medicine, Mayo Clinic, 200 1st Street S.W., Rochester, MN 55905, USA.

5. Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai Hess Center for Science and Medicine, 1470 Madison Avenue, New York, NY 10029, USA.

6. Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck Street, Boston, MA 02115, USA.

7. The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

8. Child Study Center, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

9. Department of Neurology, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205.

10. Program in Biochemistry, Cellular and Molecular Biology, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

11. Division of Genetics and Genomics, Manton Center for Orphan Disease, and Howard Hughes Medical Institute, Boston Children’s Hospital, 3 Blackfan Circle, Boston, MA 02115, USA.

12. Departments of Neurology and Pediatrics, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.

13. Lieber Institute for Brain Development, 855 North Wolfe Street, Baltimore, MD 21205, USA.

14. Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA.

15. Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.

16. Department of Cell, Developmental and Regenerative Biology, Department of Genetics and Genomic Sciences, Department of Neuroscience, Friedman Brain Institute, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

17. Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.

18. Howard Hughes Medical Institute, Laboratory of Pediatric Brain Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10065.

19. Rady Institute of Genomic Medicine, University of California, 9500 Gilman Drive, San Diego, La Jolla, CA 92093, USA.

20. Departments of Psychiatry and Behavioral Sciences and Neuroscience, 600 North Wolfe Street, Baltimore, MD 21287, USA.

21. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, 733 North Broadway, Baltimore, MD 21230, USA.

22. Department of Psychiatry and Behavioral Sciences and Department of Genetics, Stanford University School of Medicine, 3165 Porter Drive, Palo Alto, CA, 94304, USA.

23. Office of Genomics Research Coordination, National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Rockville, MD 20852, USA.

24. Autism Center of Excellence, Department of Neuroscience, School of Medicine, University of California San Diego, 8110 La Jolla Shores Drive, La Jolla, CA 92037, USA.

25. Department of Neuroscience, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

Abstract

Single-cell diversity in the brain The cells that make up an organism may all start from one genome, but somatic mutations mean that somewhere along the line of development, an organism's individual cellular genomes diverge. McConnell et al. review the implications and causes of single-cell genomic diversity for brain function. Somatic mutations caused by mobile genetic elements or errors in DNA repair may underlie certain neuropsychiatric disorders. Science , this issue p. eaal1641

Funder

National Institute of Mental Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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