Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study-Reference-Cited by-同舟云学术

Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study

Published:2020-11-13 Issue:1 Volume:7 Page:
ISSN:2052-4463
Container-title:Scientific Data
language:en
Short-container-title:Sci Data

Author:

Cai Lina^ORCID,Wheeler Eleanor^ORCID,Kerrison Nicola D.,Luan Jian’an^ORCID,Deloukas Panos^ORCID,Franks Paul W.,Amiano Pilar,Ardanaz Eva,Bonet Catalina,Fagherazzi Guy,Groop Leif C.^ORCID,Kaaks Rudolf,Huerta José María^ORCID,Masala Giovanna^ORCID,Nilsson Peter M.^ORCID,Overvad Kim^ORCID,Pala Valeria,Panico Salvatore,Rodriguez-Barranco Miguel,Rolandsson Olov,Sacerdote Carlotta,Schulze Matthias B.^ORCID,Spijkerman Annemieke M. W.,Tjonneland Anne,Tumino Rosario^ORCID,van der Schouw Yvonne T.^ORCID,Sharp Stephen J.,Forouhi Nita G.^ORCID,Riboli Elio,McCarthy Mark I.,Barroso Inês^ORCID,Langenberg Claudia^ORCID,Wareham Nicholas J.

Abstract

AbstractType 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of the largest prospective studies of T2D. Established as a nested case-cohort study to investigate the interplay between genetic and lifestyle behavioural factors on the risk of T2D, a total of 12,403 individuals were identified as incident T2D cases, and a representative sub-cohort of 16,154 individuals was selected from a larger cohort of 340,234 participants with a follow-up time of 3.99 million person-years. We describe the results from a genome-wide association analysis between more than 8.9 million SNPs and T2D risk among 22,326 individuals (9,978 cases and 12,348 non-cases) from the EPIC-InterAct study. The summary statistics to be shared provide a valuable resource to facilitate further investigations into the genetics of T2D.

Publisher

Springer Science and Business Media LLC

Subject

Library and Information Sciences,Statistics, Probability and Uncertainty,Computer Science Applications,Education,Information Systems,Statistics and Probability

Link

http://www.nature.com/articles/s41597-020-00716-7.pdf

Reference17 articles.

1. International Diabetes Federation. IDF Diabetes Atlas, 9th edn. https://www.diabetesatlas.org (2019).

2. Mahajan, A. et al. Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps Individual study design and principal investigators Europe PMC Funders Group. Nat. Genet. 50, 1505–1513 (2018).

3. Pierce, B. L. & Burgess, S. Efficient design for mendelian randomization studies: Subsample and 2-sample instrumental variable estimators. Am. J. Epidemiol. 178, 1177–1184 (2013).

4. Bowden, J., Smith, G. D., Haycock, P. C. & Burgess, S. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet. Epidemiol. 40, 304–314 (2016).

5. The InterAct Consortium. et al. The InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study. Diabetologia 54, 2272–2282 (2011).

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