Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
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Published:2018-10-08
Issue:11
Volume:50
Page:1505-1513
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Mahajan AnubhaORCID, Taliun Daniel, Thurner Matthias, Robertson Neil R., Torres Jason M., Rayner N. William, Payne Anthony J., Steinthorsdottir Valgerdur, Scott Robert A., Grarup Niels, Cook James P., Schmidt Ellen M., Wuttke Matthias, Sarnowski Chloé, Mägi Reedik, Nano Jana, Gieger Christian, Trompet Stella, Lecoeur Cécile, Preuss Michael H., Prins Bram Peter, Guo Xiuqing, Bielak Lawrence F., Below Jennifer E., Bowden Donald W., Chambers John Campbell, Kim Young Jin, Ng Maggie C. Y., Petty Lauren E., Sim Xueling, Zhang Weihua, Bennett Amanda J., Bork-Jensen Jette, Brummett Chad M., Canouil Mickaël, Ec kardt Kai-Uwe, Fischer Krista, Kardia Sharon L. R., Kronenberg Florian, Läll Kristi, Liu Ching-Ti, Locke Adam E., Luan Jian’an, Ntalla Ioanna, Nylander Vibe, Schönherr Sebastian, Schurmann Claudia, Yengo Loïc, Bottinger Erwin P., Brandslund Ivan, Christensen Cramer, Dedoussis George, Florez Jose C., Ford Ian, Franco Oscar H., Frayling Timothy M., Giedraitis Vilmantas, Hackinger Sophie, Hattersley Andrew T., Herder Christian, Ikram M. Arfan, Ingelsson Martin, Jørgensen Marit E., Jørgensen Torben, Kriebel Jennifer, Kuusisto Johanna, Ligthart Symen, Lindgren Cecilia M., Linneberg Allan, Lyssenko Valeriya, Mamakou Vasiliki, Meitinger Thomas, Mohlke Karen L., Morris Andrew D., Nadkarni Girish, Pankow James S., Peters Annette, Sattar Naveed, Stančáková Alena, Strauch Konstantin, Taylor Kent D., Thorand Barbara, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Tuomilehto Jaakko, Witte Daniel R., Dupuis Josée, Peyser Patricia A., Zeggini Eleftheria, Loos Ruth J. F., Froguel Philippe, Ingelsson Erik, Lind Lars, Groop Leif, Laakso Markku, Collins Francis S., Jukema J. Wouter, Palmer Colin N. A., Grallert Harald, Metspalu Andres, Dehghan Abbas, Köttgen Anna, Abecasis Goncalo R., Meigs James B., Rotter Jerome I., Marchini Jonathan, Pedersen Oluf, Hansen Torben, Langenberg Claudia, Wareham Nicholas J., Stefansson Kari, Gloyn Anna L., Morris Andrew P.ORCID, Boehnke MichaelORCID, McCarthy Mark I.ORCID
Publisher
Springer Science and Business Media LLC
Reference65 articles.
1. Scott, R. A. et al. An expanded genome-wide association study of type 2 diabetes in Europeans. Diabetes 66, 2888–2902 (2017). 2. Zhao, W. et al. Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. Nat. Genet. 49, 1450–1457 (2017). 3. Mahajan, A. et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat. Genet. 50, 559–571 (2018). 4. McCarthy, S. et al. A reference panel of 64,976 haplotypes for genotype imputation. Nat. Genet. 48, 1279–1283 (2016). 5. Jónsson, H. et al. Whole genome characterization of sequence diversity of 15,220 Icelanders. Sci. Data 4, 170115 (2017).
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