Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg3124.pdf
Reference153 articles.
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2. Mank, J. E., Hosken, D. J. & Wedell, N. Some inconvenient truths about sex chromosome dosage compensation and the potential role of sexual conflict. Evolution 65, 2133–2144 (2011).
3. Hallacli, E. & Akhtar, A. X chromosomal regulation in flies: when less is more. Chromosome Res. 17, 603–619 (2009).
4. Prestel, M., Feller, C., Straub, T., Mitlohner, H. & Becker, P. B. The activation potential of MOF is constrained for dosage compensation. Mol. Cell 38, 815–826 (2010). This study describes a repressive capacity within the D. melanogaster DCC that constrains the strong MOF- and H4K16ac-mediated transcriptional activation to achieve precisely twofold enhanced expression.
5. Hamada, F. N., Park, P. J., Gordadze, P. R. & Kuroda, M. I. Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster. Genes Dev. 19, 2289–2294 (2005).
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