Genetic variation may confound analysis of CRISPR-Cas9 off-target mutations
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Genetics,Molecular Biology,Biochemistry
Link
http://www.nature.com/articles/s41421-018-0025-2.pdf
Reference11 articles.
1. Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823–826 (2013).
2. Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819–823 (2013).
3. Jinek, M. et al. RNA-programmed genome editing in human cells. eLife 2, e00471 (2013).
4. Hsu, P. D., Lander, E. S. & Zhang, F. Development and applications of CRISPR-Cas9 for genome engineering. Cell 157, 1262–1278 (2014).
5. Schaefer, K. A. et al. Unexpected mutations after CRISPR–Cas9 editing in vivo. Nat. Methods 14, 547–548 (2017).
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