Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm2833.pdf
Reference105 articles.
1. Huxley, H. E. The mechanism of muscular contraction. Science 164, 1356–1365 (1969). Proposes the swinging crossbridge hypothesis, which was later called the swinging lever arm hypothesis.
2. Coureux, P. D., Sweeney, H. L. & Houdusse, A. Three myosin V structures delineate essential features of chemo-mechanical transduction. EMBO J. 23, 4527–4537 (2004).
3. Himmel, D. M. et al. Crystallographic findings on the internally uncoupled and near-rigor states of myosin: further insights into the mechanics of the motor. Proc. Natl Acad. Sci. USA 99, 12645–12650 (2002).
4. Menetrey, J. et al. The structure of the myosin VI motor reveals the mechanism of directionality reversal. Nature 435, 779–785 (2005). Presents the crystal structure of myosin VI in its post-stroke state, which reveals a redirection of the lever arm by the unique insert, first proposed here to be the source of the reverse directionality of this motor.
5. Menetrey, J., Llinas, P., Mukherjea, M., Sweeney, H. L. & Houdusse, A. The structural basis for the large powerstroke of myosin VI. Cell 131, 300–308 (2007). Presents the crystal structure of myosin VI in its pre-stroke state, and reveals an unexpected change in conformation of the converter that allows a 180° rotation of the myosin VI lever arm.
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