A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner-Reference-Cited by-同舟云学术

A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

Published:2009-11-15 Issue:12 Volume:27 Page:1186-1190
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Schellenberger Volker,Wang Chia-wei,Geething Nathan C,Spink Benjamin J,Campbell Andrew,To Wayne,Scholle Michael D,Yin Yong,Yao Yi,Bogin Oren,Cleland Jeffrey L,Silverman Joshua,Stemmer Willem P C

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/nbt.1588.pdf

Reference29 articles.

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3. Ryan, S.M., Mantovani, G., Wang, X., Haddleton, D.M. & Brayden, D.J. Advances in PEGylation of important biotech molecules: delivery aspects. Expert Opin. Drug Deliv. 5, 371–383 (2008).

4. Dhalluin, C. et al. Structural and biophysical characterization of the 40 kDa PEG-interferon-alpha2a and its individual positional isomers. Bioconjug. Chem. 16, 504–517 (2005).

5. Gaertner, H.F. & Offord, R.E. Site-specific attachment of functionalized poly(ethylene glycol) to the amino terminus of proteins. Bioconjug. Chem. 7, 38–44 (1996).

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