Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice-Reference-Cited by-同舟云学术

Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

Published:2021-06-11 Issue:1 Volume:6 Page:
ISSN:2057-3995
Container-title:npj Regenerative Medicine
language:en
Short-container-title:npj Regen Med

Author:

Zhou Yueying,Xin Xiaonan,Wang Lichao,Wang Binsheng,Chen Li,Liu Ousheng,Rowe David W.,Xu Ming^ORCID

Abstract

AbstractThe osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations.

Funder

U.S. Department of Health & Human Services | NIH | National Institute on Aging

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Developmental Biology,Biomedical Engineering,Medicine (miscellaneous)

Link

http://www.nature.com/articles/s41536-021-00145-z.pdf

Reference18 articles.

1. Ganguly, P. et al. Age-related changes in bone marrow mesenchymal stromal cells: a potential impact on osteoporosis and osteoarthritis development. Cell Transpl. 26, 1520–1529 (2017).

2. Khong, S. M. L. et al. Single-cell transcriptomics of human mesenchymal stem cells reveal age-related cellular subpopulation depletion and impaired regenerative function. Stem Cells 37, 240–246 (2019).

3. Wang, B. et al. Transplanting cells from old but not young donors causes physical dysfunction in older recipients. Aging Cell, e13106, https://doi.org/10.1111/acel.13106 (2020).