Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity-Reference-Cited by-同舟云学术

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Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity

Published:2016-01-25 Issue:3 Volume:37 Page:415-424
ISSN:1671-4083
Container-title:Acta Pharmacologica Sinica
language:en
Short-container-title:Acta Pharmacol Sin

Author:

Ma Lei-lei,Wu Zhi-tao,Wang Le,Zhang Xue-feng,Wang Jing,Chen Chen,Ni Xuan,Lin Yun-fei,Cao Yi-yi,Luan Yang,Pan Guo-yu

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Link

http://www.nature.com/articles/aps2015157.pdf

Reference37 articles.

1. Alcorn N, Saunders S, Madhok R . Benefit-risk assessment of leflunomide: an appraisal of leflunomide in rheumatoid arthritis 10 years after licensing. Drug Saf 2009; 32: 1123–34.

2. Kalgutkar AS, Nguyen HT, Vaz AD, Doan A, Dalvie DK, McLeod DG, et al. In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes. Drug Metab Dispos 2003; 31: 1240–50.

3. Legras A, Bergemer-Fouquet AM, Jonville-Bera AP . Fatal hepatitis with leflunomide and itraconazole. Am J Med 2002; 113: 352–3.

4. Seah QM, New LS, Chan EC, Boelsterli UA . Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726. Drug Metab Lett 2008; 2: 153–7.

5. Shi Q, Yang X, Greenhaw J, Salminen WF . Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes. Toxicol Sci 2011; 122: 579–86.

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