IN VITRO METABOLISM STUDIES ON THE ISOXAZOLE RING SCISSION IN THE ANTI-INFLAMMATORY AGENT LEFLUNOMIDE TO ITS ACTIVE α-CYANOENOL METABOLITE A771726: MECHANISTIC SIMILARITIES WITH THE CYTOCHROME P450-CATALYZED DEHYDRATION OF ALDOXIMES-Reference-Cited by-同舟云学术

IN VITRO METABOLISM STUDIES ON THE ISOXAZOLE RING SCISSION IN THE ANTI-INFLAMMATORY AGENT LEFLUNOMIDE TO ITS ACTIVE α-CYANOENOL METABOLITE A771726: MECHANISTIC SIMILARITIES WITH THE CYTOCHROME P450-CATALYZED DEHYDRATION OF ALDOXIMES

Published:2003-09-15 Issue:10 Volume:31 Page:1240-1250
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Kalgutkar Amit S.,Nguyen Hang T.,Vaz Alfin D. N.,Doan Anke,Dalvie Deepak K.,McLeod Dale G.,Murray John C.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference32 articles.

1. A New Rational Hypothesis for the Pharmacophore of the Active Metabolite of Leflunomide, a Potent Immunosuppressive Drug

2. Dehydration of Alkyl- and Arylaldoximes as a New Cytochrome P450-Catalyzed Reaction: Mechanism and Stereochemical Characteristics

3. Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

4. The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate Dehydrogenase

Cited by 108 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Periodate activation and pH regulation using ball-milled metal-oxide-mineral-biochar composite for removal of antibiotics from contaminated water;Environmental Research;2024-11

2. Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability;Journal of Medicinal Chemistry;2024-05-29

3. Novel Leflunomide Analog, UTLOH-4e, Ameliorates Gouty Arthritis Induced by Monosodium Urate Via NF-κB/NLRP3 Signaling Pathway;Current Pharmaceutical Biotechnology;2024-02

4. Engineering of a P450-based Kemp eliminase with a new mechanism;Chinese Journal of Catalysis;2023-04

5. Toxicological data bank bridges the gap between environmental risk assessment and green organic chemical design in One Health world;Green Chemistry;2023