MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors

Author:

Knorr K L B,Schneider P A,Meng X W,Dai H,Smith B D,Hess A D,Karp J E,Kaufmann S H

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Reference59 articles.

1. Soucy TA, Smith PG, Milhollen MA, Berger AJ, Gavin JM, Adhikari S et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 2009; 458: 732–736.

2. Nawrocki ST, Griffin P, Kelly KR, Carew JS . MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy. Expert Opin Investig Drugs 2012; 21: 1563–1573.

3. Sen S, De Leon JP, Smith PG, Roboz GJ, Guzman ML . Investigational NEDD8-activating enzyme (NAE) inhibitor, MLN4924, demonstrates activity against primary AML blast, progenitor and stem cell populations. ASH Annu Meet Abstr 2011; 118: 1414.

4. Swords RT, Erba HP, DeAngelo DJ, Smith PG, Pickard MD, Dezube BJ et al. The novel, investigational NEDD8-activating enzyme inhibitor MLN4924 in adult patients with acute myeloid leukemia (AML) or high-grade myelodysplastic syndromes (MDS): a phase 1 study. ASH Annu Meet Abstr 2010; 116: 658.

5. Swords RT, Kelly KR, Smith PG, Garnsey JJ, Mahalingam D, Medina E et al. Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia. Blood 2010; 115: 3796–3800.

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