Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells

Author:

Chan I H,Jain R,Tessmer M S,Gorman D,Mangadu R,Sathe M,Vives F,Moon C,Penaflor E,Turner S,Ayanoglu G,Chang C,Basham B,Mumm J B,Pierce R H,Yearley J H,McClanahan T K,Phillips J H,Cua D J,Bowman E P,Kastelein R A,LaFace D

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Reference41 articles.

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2. Grivennikov, S.I., Greten, F.R. & Karin, M. Immunity, inflammation, and cancer. Cell 140, 883–899 (2010).

3. Grivennikov, S. et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15, 103–113 (2009).

4. Popivanova, B.K. et al. Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J. Clin. Invest. 118, 560–570 (2008).

5. Ernst, M. et al. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. J. Clin. Invest. 118, 1727–1738 (2008).

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