The crosstalk between ILC3s and adaptive immunity in diseases

Author:

Wang Wenyan123,Li Na123,Guo Xiaohuan123ORCID

Affiliation:

1. Institute for Immunology Tsinghua University Beijing China

2. Department of Basic Medical Sciences, School of Medicine Tsinghua University Beijing China

3. Beijing Key Lab for Immunological Research on Chronic Diseases Tsinghua University Beijing China

Abstract

RORγt+ group 3 innate lymphoid cells (ILC3s), the innate counterpart of Th17 cells, are enriched in the mucosal area and lymphoid tissues. ILC3s interact with a variety of cells through their effector molecules and play an important role in the host defense against a spectrum of infections. Recent studies suggest that the extensive crosstalk between ILC3s and adaptive immune cells, especially T cells, is essential for maintaining tissue homeostasis. Here we discuss recent advances in the crosstalk between ILC3s and adaptive immune responses in multiple tissues and diseases. Understanding how ILC3s engage with adaptive immune cells will enhance our comprehension of diseases and facilitate the identification of novel therapeutic targets.

Funder

Natural Science Foundation of Beijing Municipality

National Basic Research Program of China

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

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