Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology
Link
http://www.nature.com/articles/s41556-018-0122-3.pdf
Reference70 articles.
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3. Rosciglione, S., Theriault, C., Boily, M. O., Paquette, M. & Lavoie, C. Gαs regulates the post-endocytic sorting of G protein-coupled receptors. Nat. Commun. 5, 4556 (2014).
4. Drelon, C. et al. PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development. Nat. Commun. 7, 12751 (2016).
5. He, X. et al. The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nat. Med. 20, 1035–1042 (2014).
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