Abstract
AbstractCurrent non-invasive neuroimaging methods can assess neural activity in all areas of the human brain but the olfactory bulb (OB). The OB has been suggested to fulfill a role comparable to that of V1 and the thalamus in the visual system and have been closely linked to a wide range of olfactory tasks and neuropathologies. Here we present a method for non-invasive recording of signals from the human OB with millisecond precision. We demonstrate that signals obtained via recordings from EEG electrodes at the nasal bridge represent responses from the human olfactory bulb - recordings we term Electrobulbogram (EBG). The EBG will aid future olfactory-related translational work but can also potentially be implemented as an everyday clinical tool to detect pathology-related changes in human central olfactory processing in neurodegenerative diseases. In conclusion, the EBG is localized to the OB, is reliable, and follows response patterns demonstrated in non-human animal models.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference57 articles.
1. Wilson, D. A. & Sullivan, R. M. Cortical processing of odor objects. Neuron 72, 506–519 (2011).
2. Biskamp, J., Bartos, M. & Sauer, J.-F. Organization of prefrontal network activity by respiration-related oscillations. Sci. Rep. 7, 45508 (2017).
3. Laurent, G. Olfactory network dynamics and the coding of multidimensional signals. Nat. Rev. Neurosci. 3, 884–895 (2002).
4. Shepherd, G., Chen, W. & Greer, C. in The Synaptic Organization of the Brain (ed. Shepherd, G.) (Oxford University Press, U.S.A., 2004).
5. Kay, L. M. & Sherman, S. M. An argument for an olfactory thalamus. Trends Neurosci. 30, 47–53 (2007).
Cited by
53 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献