Association analyses identify 31 new risk loci for colorectal cancer susceptibility
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Published:2019-05-14
Issue:1
Volume:10
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Law Philip J.ORCID, , Timofeeva MariaORCID, Fernandez-Rozadilla CeresORCID, Broderick PeterORCID, Studd JamesORCID, Fernandez-Tajes Juan, Farrington SusanORCID, Svinti VictoriaORCID, Palles Claire, Orlando Giulia, Sud AmitORCID, Holroyd Amy, Penegar Steven, Theodoratou Evropi, Vaughan-Shaw Peter, Campbell Harry, Zgaga Lina, Hayward CarolineORCID, Campbell ArchieORCID, Harris Sarah, Deary Ian J., Starr John, Gatcombe Laura, Pinna Maria, Briggs Sarah, Martin LynnORCID, Jaeger Emma, Sharma-Oates Archana, East JamesORCID, Leedham Simon, Arnold Roland, Johnstone Elaine, Wang Haitao, Kerr David, Kerr Rachel, Maughan Tim, Kaplan RichardORCID, Al-Tassan NadaORCID, Palin KimmoORCID, Hänninen Ulrika A., Cajuso Tatiana, Tanskanen Tomas, Kondelin Johanna, Kaasinen Eevi, Sarin Antti-Pekka, Eriksson Johan G., Rissanen Harri, Knekt Paul, Pukkala Eero, Jousilahti Pekka, Salomaa VeikkoORCID, Ripatti Samuli, Palotie Aarno, Renkonen-Sinisalo Laura, Lepistö Anna, Böhm Jan, Mecklin Jukka-Pekka, Buchanan Daniel D.ORCID, Win Aung-KoORCID, Hopper John, Jenkins Mark E.ORCID, Lindor Noralane M., Newcomb Polly A., Gallinger Steven, Duggan David, Casey Graham, Hoffmann Per, Nöthen Markus M., Jöckel Karl-Heinz, Easton Douglas F.ORCID, Pharoah Paul D. P.ORCID, Peto Julian, Canzian Federico, Swerdlow Anthony, Eeles Rosalind A.ORCID, Kote-Jarai Zsofia, Muir KennethORCID, Pashayan NoraORCID, Harkin AndreaORCID, Allan Karen, McQueen John, Paul JamesORCID, Iveson Timothy, Saunders Mark, Butterbach Katja, Chang-Claude Jenny, Hoffmeister Michael, Brenner Hermann, Kirac Iva, Matošević Petar, Hofer PhilippORCID, Brezina StefanieORCID, Gsur Andrea, Cheadle Jeremy P.ORCID, Aaltonen Lauri A., Tomlinson IanORCID, Houlston Richard S.ORCID, Dunlop Malcolm G.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference71 articles.
1. Graff, R. E. et al. Familial risk and heritability of colorectal cancer in the nordic twin study of cancer. Clin. Gastroenterol. Hepatol. 15, 1256–1264 (2017). 2. Schmit, S. L. et al. Novel common genetic susceptibility loci for colorectal cancer. J. Natl. Cancer Inst. 111, 146–157 (2018). 3. Orlando, G. et al. Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease. Hum. Mol. Genet 25, 2349–2359 (2016). 4. Tanikawa, C. et al. GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12. Carcinogenesis 39, 652–660 (2018). 5. Zeng, C. et al. Identification of susceptibility loci and genes for colorectal cancer risk. Gastroenterology 150, 1633–1645 (2016).
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