Cellular reprogramming as a tool to model human aging in a dish-Reference-Cited by-同舟云学术

Cellular reprogramming as a tool to model human aging in a dish

Published:2024-02-28 Issue:1 Volume:15 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Pitrez Patricia R.^ORCID,Monteiro Luis M.^ORCID,Borgogno Oliver,Nissan Xavier^ORCID,Mertens Jerome,Ferreira Lino^ORCID

Abstract

AbstractThe design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.

Funder

U.S. Department of Health & Human Services | NIH | National Institute on Aging

EC | Horizon 2020 Framework Programme

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41467-024-46004-5.pdf

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