CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage-Reference-Cited by-同舟云学术

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

Published:2019-01-03 Issue:1 Volume:10 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Sun Jichao,Carlson-Stevermer Jared,Das Utpal,Shen Minjie,Delenclos Marion,Snead Amanda M.,Koo So Yeon,Wang Lina,Qiao Dianhua,Loi Jonathan,Petersen Andrew J.,Stockton Michael^ORCID,Bhattacharyya Anita,Jones Mathew V.,Zhao Xinyu^ORCID,McLean Pamela J.,Sproul Andrew A.,Saha Krishanu^ORCID,Roy Subhojit

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-018-07971-8.pdf

Reference43 articles.

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2. Yang, S. et al. CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington’s disease. J. Clin. Invest 127, 2719–2724 (2017).

3. Park, C. Y. et al. Reversion of FMR1 methylation and silencing by editing the triplet repeats in fragile X iPSC-derived neurons. Cell Rep. 13, 234–241 (2015).

4. Gyorgy, B. et al. CRISPR/Cas9 mediated disruption of the Swedish APP allele as a therapeutic approach for early-onset Alzheimer’s disease. Mol. Ther. Nucleic Acids 11, 429–440 (2018).

5. McMahon, M. A. & Cleveland, D. W. Gene therapy: gene-editing therapy for neurological disease. Nat. Rev. Neurol. 13, 7–9 (2017).

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