Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation-Reference-Cited by-同舟云学术

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation

Published:2018-01-23 Issue:1 Volume:9 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Naumann Marcel,Pal Arun,Goswami Anand,Lojewski Xenia,Japtok Julia,Vehlow Anne,Naujock Maximilian,Günther René,Jin Mengmeng,Stanslowsky Nancy,Reinhardt Peter,Sterneckert Jared,Frickenhaus Marie,Pan-Montojo Francisco,Storkebaum Erik,Poser Ina,Freischmidt Axel,Weishaupt Jochen H.,Holzmann Karlheinz,Troost Dirk,Ludolph Albert C.,Boeckers Tobias M.,Liebau Stefan,Petri Susanne,Cordes Nils,Hyman Anthony A.,Wegner Florian,Grill Stephan W.,Weis Joachim,Storch Alexander,Hermann Andreas

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-017-02299-1.pdf

Reference49 articles.

1. Vance, C. et al. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science 323, 1208–1211 (2009).

2. Kwiatkowski, T. J. Jr et al. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science 323, 1205–1208 (2009).

3. Mackenzie, I. R., Rademakers, R. & Neumann, M. TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. Lancet Neurol. 9, 995–1007 (2010).

4. Dormann, D. et al. ALS-associated fused in sarcoma (FUS) mutations disrupt transportin-mediated nuclear import. EMBO J. 29, 2841–2857 (2010).

5. Dormann, D. et al. Arginine methylation next to the PY-NLS modulates transportin binding and nuclear import of FUS. EMBO J. 31, 4258–4275 (2012).

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