Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS

Author:

Dormann Dorothee1,Madl Tobias234,Valori Chiara F56,Bentmann Eva1,Tahirovic Sabina7,Abou-Ajram Claudia1,Kremmer Elisabeth8,Ansorge Olaf9,Mackenzie Ian R A10,Neumann Manuela5611,Haass Christian1712

Affiliation:

1. Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University; Munich Germany

2. NMR Spectroscopy, Karl-Franzens University; Graz Austria

3. Institute of Structural Biology, Helmholtz Zentrum München; Neuherberg Germany

4. Biomolecular NMR, Department of Chemistry, Technische Universität München; Garching Germany

5. Institute of Neuropathology, University Hospital Zurich; Zurich Switzerland

6. DZNE-German Center for Neurodegenerative Diseases; Tübingen Germany

7. DZNE-German Center for Neurodegenerative Diseases; Munich Germany

8. Institute of Molecular Immunology, Helmholtz Zentrum München; Munich Germany

9. Department of Neuropathology, John Radcliffe Hospital; Oxford UK

10. Department of Pathology, Vancouver General Hospital; Vancouver Canada

11. Department of Neuropathology, University of Tübingen; Tübingen Germany

12. Munich Cluster for Systems Neurology (SyNergy); Munich Germany

Publisher

Wiley

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Reference76 articles.

1. Methylation of Xenopus CIRP2 regulates its arginine- and glycine-rich region-mediated nucleocytoplasmic distribution;Aoki;Nucleic Acids Res,2002

2. Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain;Aoki;Acta Neuropathol,2012

3. Transcriptional down-regulation through nuclear exclusion of EWS methylated by PRMT1;Araya;Biochem Biophys Res Commun,2005

4. Effects of adenosine dialdehyde on S-adenosylhomocysteine hydrolase and S-adenosylmethionine-dependent transmethylations in mouse L929 cells;Bartel;Mol Pharmacol,1984

5. Juvenile ALS with basophilic inclusions is a FUS proteinopathy with FUS mutations;Baumer;Neurology,2010

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