Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors-Reference-Cited by-同舟云学术

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

Published:2017-11-15 Issue:1 Volume:8 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Dahlin Jayme L.^ORCID,Nelson Kathryn M.^ORCID,Strasser Jessica M.^ORCID,Barsyte-Lovejoy Dalia,Szewczyk Magdalena M.,Organ Shawna,Cuellar Matthew^ORCID,Singh Gurpreet,Shrimp Jonathan H.^ORCID,Nguyen Nghi^ORCID,Meier Jordan L.^ORCID,Arrowsmith Cheryl H.,Brown Peter J.,Baell Jonathan B.^ORCID,Walters Michael A.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-017-01657-3.pdf

Reference69 articles.

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3. Thorne, N., Auld, D. S. & Inglese, J. Apparent activity in high-throughput screening: origins of compound-dependent assay interference. Curr. Opin. Chem. Biol. 14, 315–324 (2010).

4. Baell, J. B. & Holloway, G. A. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. J. Med. Chem. 53, 2719–2740 (2010).

5. Jasial, S., Hu, Y. & Bajorath, J. How frequently are pan-assay interference compounds active? Large-scale analysis of screening data reveals diverse activity profiles, low global hit frequency, and many consistently inactive compounds. J. Med. Chem. 60, 3879–3886 (2017).

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