Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-Lactamase-Reference-Cited by-同舟云学术

Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-Lactamase

Published:2008-03-12 Issue:8 Volume:51 Page:2502-2511
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Babaoglu Kerim¹,Simeonov Anton¹,Irwin John J.¹,Nelson Michael E.¹,Feng Brian¹,Thomas Craig J.¹,Cancian Laura¹,Costi M. Paola¹,Maltby David A.¹,Jadhav Ajit¹,Inglese James¹,Austin Christopher P.¹,Shoichet Brian K.¹

Affiliation:

1. Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158-2330, NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-3370, Mass Spectroscopy Facility, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94143-0446, and Dipartimento di Scienze Farmaceutiche, Università degli Studi di Modena e Reggio Emilia, Via Campi 183,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm701500e

Reference47 articles.

1. Recognizing molecules with drug-like properties

2. Utilization of NMR-Derived Fragment Leads in Drug Design

3. Reactive compounds and in vitro false positives in HTS

4. A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

5. A Specific Mechanism of Nonspecific Inhibition

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