Analysis of transcriptional changes in the immune system associated with pubertal development in a longitudinal cohort of children with asthma
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Published:2023-01-16
Issue:1
Volume:14
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Resztak Justyna A.ORCID, Choe JaneORCID, Nirmalan ShreyaORCID, Wei Julong, Bruinsma Julian, Houpt Russell, Alazizi Adnan, Mair-Meijers Henriette E., Wen XiaoquanORCID, Slatcher Richard B., Zilioli Samuele, Pique-Regi Roger, Luca FrancescaORCID
Abstract
AbstractPuberty is an important developmental period marked by hormonal, metabolic and immune changes. Puberty also marks a shift in sex differences in susceptibility to asthma. Yet, little is known about the gene expression changes in immune cells that occur during pubertal development. Here we assess pubertal development and leukocyte gene expression in a longitudinal cohort of 251 children with asthma. We identify substantial gene expression changes associated with age and pubertal development. Gene expression changes between pre- and post-menarcheal females suggest a shift from predominantly innate to adaptive immunity. We show that genetic effects on gene expression change dynamically during pubertal development. Gene expression changes during puberty are correlated with gene expression changes associated with asthma and may explain sex differences in prevalence. Our results show that molecular data used to study the genetics of early onset diseases should consider pubertal development as an important factor that modifies the transcriptome.
Funder
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
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