Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL-Reference-Cited by-同舟云学术

Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL

Published:2017-10-20 Issue:1 Volume:8 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Karpel-Massler Georg,Ishida Chiaki Tsuge,Bianchetti Elena,Zhang Yiru,Shu Chang,Tsujiuchi Takashi,Banu Matei A.,Garcia Franklin,Roth Kevin A.,Bruce Jeffrey N.,Canoll Peter,Siegelin Markus D.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-017-00984-9.pdf

Reference40 articles.

1. Louis, D. N. et al. The 2016 world health organization classification of tumors of the central nervous system: a summary. Acta Neuropathol. 131, 803–820 (2016).

2. Clark, O., Yen, K. & Mellinghoff, I. K. Molecular pathways: isocitrate dehydrogenase mutations in cancer. Clin. Cancer Res. 22, 1837–1842 (2016).

3. Fu, X. et al. 2-Hydroxyglutarate inhibits ATP synthase and mTOR signaling. Cell Metab. 22, 508–515 (2015).

4. Willis, S. N. et al. Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 19, 1294–1305 (2005).

5. Schmidt, E. K., Clavarino, G., Ceppi, M. & Pierre, P. SUnSET, a nonradioactive method to monitor protein synthesis. Nat. Methods 6, 275–277 (2009).

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