1. Gerczuk, P. Z. & Kloner, R. A. An update on cardioprotection: a review of the latest adjunctive therapies to limit myocardial infarction size in clinical trials. J. Am. Coll. Cardiol. 59, 969–978 (2012).
2. Roger, V. L. et al. Heart disease and stroke statistics—2012 update: a report from the American Heart Association. Circulation 125, e2–e220 (2012).
3. Vlahos, C. J., McDowell, S. A. & Clerk, A. Kinases as therapeutic targets for heart failure. Nat. Rev. 2, 99–113 (2003).
4. Force, T. & Kolaja, K. L. Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes. Nat. Rev. 10, 111–126 (2011).
5. Mochly-Rosen, D., Das, K. & Grimes, K. V. Protein kinase C, an elusive therapeutic target? Nat. Rev. 11, 937–957 (2012).