Enhancing Mitochondrial Function: A Novel Therapeutic Target for Alzheimer's Disease

Abstract

Alzheimer's Disease (AD) is a common neurodegenerative disease caused by the gradual degradation of neurons. Current therapies for AD primarily relieve symptoms. However, a comprehensive understanding of the fundamental processes of AD progression is still lacking. Mitochondrial dysfunction is a central factor in the etiology of AD. Numerous studies have shown that mitochondrial function is severely impaired during the development of AD. There has been much interest in preliminary research on the different treatment methods for mitochondrial dysfunction. Nonetheless, clinical trials have shown little progress to date. This article aims to review the various aspects of the changes in mitochondrial dynamics observed in Alzheimer's, which may impact the progression of this severe condition. Furthermore, we investigated therapeutic approaches that aim to enhance mitochondrial dynamics and function, potentially providing a different approach to overcome the limitations of amyloid-directed therapy.